Progesterone Receptor

NR3C3

Progesterone Receptor

Related Products

Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.

Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.

In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).

Progesterone Receptor Related Products (134)
Antibodies (2)

By Effects:	Inhibitors (10) Ligand (1) Agonists (71) Antagonists (20) Activators (7) Modulators (6)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B0084R

Dienogest (Standard)	Agonist
Dienogest (Standard) is the analytical standard of Dienogest. This product is intended for research and analytical applications. Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia.

HY-105177

ORG 33628	Modulator
ORG 33628 is a potent and selective progesterone receptor modulator. ORG 33628 shows anti-progestational and anti-glucocorticoid activity. ORG 33628 shows ovulation-inhibitory activity. ORG 33628 has the potential for the research of breast and endometrium.

HY-W009066

2-Ethylhexyl diphenyl phosphate	Activator
2-Ethylhexyl diphenyl phosphate is an organophosphate flame retardants (OPFRs) and a PPARG agonist (EC₂₀: 2.04 µM). 2-Ethylhexyl diphenyl phosphate also inhibits ERRγ transcriptional activity (IC₅₀: 1.3 µM). 2-Ethylhexyl diphenyl phosphate upregulates 3β-HSD1, human chorionic gonadotropin (hCG) and progesterone secretion. 2-Ethylhexyl diphenyl phosphate can be used in studies of female reproduction and fetal development.

HY-105634AR

Nomegestrol acetate (Standard)	Agonist
Nomegestrol acetate (Standard) is the analytical standard of Nomegestrol acetate. This product is intended for research and analytical applications. Nomegestrol acetate is an orally active, highly selective progestogen and a progesterone receptor complete agonist. Nomegestrol acetate inhibits ovulation. Nomegestrol acetate is also effective in inhibiting the proliferation of human endometrial cancer RL95-2 cells in vitro and in vivo. Nomegestrol acetate can be used in cancer (especially endometrial cancer) and contraceptive studies.

HY-139244S

Norgestimate-d₆
Norgestimate-d₆ is the deuterium labeled Norgestimate. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2]. Norgestimate-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B1089R

Ethynodiol diacetate (Standard)	Agonist
Ethynodiol diacetate (Standard) is the analytical standard of Ethynodiol diacetate. This product is intended for research and analytical applications. Ethynodiol diacetate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0084S3

Dienogest-¹³C₂,¹⁵N	Agonist
Dienogest-¹³C₂,¹⁵N (STS 557-¹³C₂,¹⁵N) is ¹³C- and ¹⁵N-labeled Dienogest (HY-B0084).

HY-17375R

Allylestrenol (Standard)
Allylestrenol (Standard) is the analytical standard of Allylestrenol. This product is intended for research and analytical applications. Allylestrenol, a synthetic sexualsteroid, is used worldwide in case of endangered pregnancies.

HY-106827S1

Trimegestone-¹³C,d₃	Inhibitor
Trimegestone-¹³C,d₃ is ¹³C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC₅₀ value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC₅₀=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes.

HY-105820

Algestone	Agonist
Algestone is a progestin that exhibits hormonal contraceptive effects.

HY-14959S

Ulipristal-d₃	Modulator
Ulipristal-d₃ (CDB-3236-d₃) is deuterium labeled Ulipristal. Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system.

HY-N0347

17α-Hydroxyprogesterone acetate
17α-Hydroxyprogesterone acetate possesses progestational activity. 17α-Hydroxyprogesterone acetate has antiinflammatory effects at the murine maternal-fetal interface.

HY-B0521R

Altrenogest (Standard)	Agonist
Altrenogest (Standard) is the analytical standard of Altrenogest. This product is intended for research and analytical applications. Altrenogest (Allyltrenbolone) is a progestogen structurally related to veterinary steroid trenbolone.

HY-U00091

Gestonorone Capronate
Gestonorone Capronate is a progestin for the treatment of benign prostatic hypertrophy and endometrial cancer.

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Progesterone Receptor

Progesterone Receptor

Progesterone Receptor Related Products (134)

Antibodies (2)

Progesterone Receptor Related Products (134):